Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes

A monoclonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of covalent αDEC205–antigen adducts. These adducts can induce antigen-specific T-cell immune responses or tolerance. We exploit the transpeptidase act...

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Bibliographic Details
Main Authors: Swee, Lee Kim, Guimaraes, Carla P., Sehrawat, Sharvan, Spooner, Eric, Barrasa, M. Inmaculada, Ploegh, Hidde L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557095/
https://ncbi.nlm.nih.gov/pubmed/23297227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214994110
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