Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Immature CD4(+)CD8(+) (double-positive (DP)) thymocytes are signaled via T cell antigen receptors (TCRs) to undergo positive selection and become responsive to intrathymic cytokines such as interleukin 7 (IL-7). We report here that cytokine signaling is required for positively selected thymocytes to...

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Main Authors: Park, Jung-Hyun, Adoro, Stanley, Guinter, Terry, Erman, Batu, Alag, Amala S, Catalfamo, Marta, Kimura, Motoko Y, Cui, Yongzhi, Lucas, Philip J, Gress, Ronald E, Kubo, Masato, Hennighausen, Lothar, Feigenbaum, Lionel, Singer, Alfred
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555225/
https://ncbi.nlm.nih.gov/pubmed/20118929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1840
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