Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index

AIMS: To evaluate the effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites in relation to the CYP2B6*6 genotype and explore potential phenotyping indices for CYP2B6 activity in vivo using a low dose of oral efavirenz. METHODS: We conducted a randomized...

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Bibliographische Detailangaben
Hauptverfasser: Jiang, Fen, Desta, Zeruesenay, Shon, Ji-Hong, Yeo, Chang-Woo, Kim, Ho-Sook, Liu, Kwang-Hyeon, Bae, Soo-Kyung, Lee, Sang-Seop, Flockhart, David A, Shin, Jae-Gook
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2013
Schlagworte:
Methods in Clinical Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555064/
https://ncbi.nlm.nih.gov/pubmed/22554354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04314.x
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