Molecular Determinants of Subtype-selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors

Deciphering which specific agonist-receptor interactions affect efficacy levels is of high importance, because this will ultimately aid in designing selective drugs. The novel compound NS3861 and cytisine are agonists of nicotinic acetylcholine receptors (nAChRs) and both bind with high affinity to...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Harpsøe, Kasper, Hald, Helle, Timmermann, Daniel B., Jensen, Marianne L., Dyhring, Tino, Nielsen, Elsebet Ø., Peters, Dan, Balle, Thomas, Gajhede, Michael, Kastrup, Jette S., Ahring, Philip K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554923/
https://ncbi.nlm.nih.gov/pubmed/23229547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436337
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