Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine α4β2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED

The α4β2 subtype of the nicotinic acetylcholine receptor has been pursued as a drug target for treatment of psychiatric and neurodegenerative disorders and smoking cessation aids for decades. Still, a thorough understanding of structure-function relationships of α4β2 agonists is lacking. Using bindi...

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Detalhes bibliográficos
Main Authors: Rohde, Line Aagot Hede, Ahring, Philip Kiær, Jensen, Marianne Lerbech, Nielsen, Elsebet Østergaard, Peters, Dan, Helgstrand, Charlotte, Krintel, Christian, Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm, Balle, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281707/
https://ncbi.nlm.nih.gov/pubmed/22170047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292243
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