A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of the secretory proteins. Mechanisms of targeting of nonglycosylated proteins are less clear. Here, we studied three nonglycosylated proteins a...

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Autors principals: Shenkman, Marina, Groisman, Bella, Ron, Efrat, Avezov, Edward, Hendershot, Linda M., Lederkremer, Gerardo Z.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554889/
https://ncbi.nlm.nih.gov/pubmed/23233672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438275
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