A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of the secretory proteins. Mechanisms of targeting of nonglycosylated proteins are less clear. Here, we studied three nonglycosylated proteins a...

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Detalles Bibliográficos
Main Authors: Shenkman, Marina, Groisman, Bella, Ron, Efrat, Avezov, Edward, Hendershot, Linda M., Lederkremer, Gerardo Z.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554889/
https://ncbi.nlm.nih.gov/pubmed/23233672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438275
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