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Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates
Extensive mannose trimming of nascent glycoprotein N-glycans signals their targeting to endoplasmic reticulum-associated degradation (ERAD). ER mannosidase I (ERManI) and the EDEM protein family participate in this process. However, whether the EDEMs are truly mannosidases can be addressed only by m...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6194124/ https://ncbi.nlm.nih.gov/pubmed/30374462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0174-8 |
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