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Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates
Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD), acts as a timer enzyme, modifying N-linked sugar chains of glycoproteins with time. This process halts glycoprotein folding attempts when necessary and targets terminall...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294666/ https://ncbi.nlm.nih.gov/pubmed/25411339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1152 |
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