Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD), acts as a timer enzyme, modifying N-linked sugar chains of glycoproteins with time. This process halts glycoprotein folding attempts when necessary and targets terminall...

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Udgivet i:Mol Biol Cell
Main Authors: Benyair, Ron, Ogen-Shtern, Navit, Mazkereth, Niv, Shai, Ben, Ehrlich, Marcelo, Lederkremer, Gerardo Z.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294666/
https://ncbi.nlm.nih.gov/pubmed/25411339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1152
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