A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of the secretory proteins. Mechanisms of targeting of nonglycosylated proteins are less clear. Here, we studied three nonglycosylated proteins a...

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Détails bibliographiques
Auteurs principaux: Shenkman, Marina, Groisman, Bella, Ron, Efrat, Avezov, Edward, Hendershot, Linda M., Lederkremer, Gerardo Z.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Protein Synthesis and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554889/
https://ncbi.nlm.nih.gov/pubmed/23233672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438275
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