High Doses of Romiplostim Induce Proliferation and Reduce Proplatelet Formation by Human Megakaryocytes

BACKGROUND: Romiplostim (AMG531) is a Thrombopoietin (TPO) receptor agonist with no homology with the endogenous TPO that has been used to treat patients affected by immune thrombocytopenia (ITP). Despite the use of TPO mimetics in the clinical practice, the mechanisms underlying their impact on meg...

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Bibliographic Details
Main Authors: Currao, Manuela, Balduini, Carlo L., Balduini, Alessandra
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554640/
https://ncbi.nlm.nih.gov/pubmed/23359807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054723
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