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Outside-In Signalling Generated by a Constitutively Activated Integrin α(IIb)β(3) Impairs Proplatelet Formation in Human Megakaryocytes
BACKGROUND: The interaction of megakaryocytes with matrix proteins of the osteoblastic and vascular niche is essential for megakaryocyte maturation and proplatelet formation. Fibrinogen is present in the vascular niche and the fibrinogen receptor α(IIb)β(3) is abundantly expressed on megakaryocytes,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335122/ https://ncbi.nlm.nih.gov/pubmed/22539947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034449 |
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