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Outside-In Signalling Generated by a Constitutively Activated Integrin α(IIb)β(3) Impairs Proplatelet Formation in Human Megakaryocytes

BACKGROUND: The interaction of megakaryocytes with matrix proteins of the osteoblastic and vascular niche is essential for megakaryocyte maturation and proplatelet formation. Fibrinogen is present in the vascular niche and the fibrinogen receptor α(IIb)β(3) is abundantly expressed on megakaryocytes,...

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Bibliografiske detaljer
Main Authors: Bury, Loredana, Malara, Alessandro, Gresele, Paolo, Balduini, Alessandra
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335122/
https://ncbi.nlm.nih.gov/pubmed/22539947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034449
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