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High Doses of Romiplostim Induce Proliferation and Reduce Proplatelet Formation by Human Megakaryocytes
BACKGROUND: Romiplostim (AMG531) is a Thrombopoietin (TPO) receptor agonist with no homology with the endogenous TPO that has been used to treat patients affected by immune thrombocytopenia (ITP). Despite the use of TPO mimetics in the clinical practice, the mechanisms underlying their impact on meg...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554640/ https://ncbi.nlm.nih.gov/pubmed/23359807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054723 |
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