Trimeric Glycosylphosphatidylinositol-Anchored HCDR3 of Broadly Neutralizing Antibody PG16 Is a Potent HIV-1 Entry Inhibitor

PG9 and PG16 are two quaternary-structure-specific broadly neutralizing antibodies with unique HCDR3 subdomains. Previously, we showed that glycosylphosphatidylinositol (GPI)-anchored HCDR3 subdomains (GPI-HCDR3) can be targeted to lipid rafts of the plasma membrane, bind to the epitope recognized b...

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Bibliographic Details
Main Authors: Liu, Lihong, Wang, Weiming, Yang, Lifei, Ren, Huanhuan, Kimata, Jason T., Zhou, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554188/
https://ncbi.nlm.nih.gov/pubmed/23152526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01038-12
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