Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

PG9 is the founder member of an expanding family of glycan-dependent human antibodies that preferentially bind the HIV (HIV-1) envelope (Env) glycoprotein (gp) trimer and broadly neutralize the virus. Here, we show that a soluble SOSIP.664 gp140 trimer constructed from the Clade A BG505 sequence bin...

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Main Authors: Julien, Jean-Philippe, Lee, Jeong Hyun, Cupo, Albert, Murin, Charles D., Derking, Ronald, Hoffenberg, Simon, Caulfield, Michael J., King, C. Richter, Marozsan, Andre J., Klasse, Per Johan, Sanders, Rogier W., Moore, John P., Wilson, Ian A., Ward, Andrew B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600498/
https://ncbi.nlm.nih.gov/pubmed/23426631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217537110
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