The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1

The variable regions (VHHs) of two heavy chain-only antibodies, JM2 and JM4, from llamas that have been immunized with a trimeric gp140 bound to a CD4 mimic have been recently isolated (here referred to as VHH JM2 and VHH JM4, respectively). JM2 binds the CD4-binding site of gp120 and neutralizes HI...

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Publicado en:J Virol
Autores principales: Liu, Lihong, Wang, Weiming, Matz, Julie, Ye, Chaobaihui, Bracq, Lucie, Delon, Jerome, Kimata, Jason T., Chen, Zhiwei, Benichou, Serge, Zhou, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110191/
https://ncbi.nlm.nih.gov/pubmed/27654286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01559-16
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