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Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity

In previous studies, we demonstrated that single-chain variable fragments (scFvs) from anti-human immunodeficiency virus (HIV) Env monoclonal antibodies act as entry inhibitors when tethered to the surface of target cells by a glycosyl-phosphatidylinositol (GPI) anchor. Interestingly, even if a viru...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Misra, Anisha, Gleeson, Emile, Wang, Weiming, Ye, Chaobaihui, Zhou, Paul, Kimata, Jason T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972903/
https://ncbi.nlm.nih.gov/pubmed/29321330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02080-17
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