Anti-prion activity of an RNA aptamer and its structural basis

Prion proteins (PrPs) cause prion diseases, such as bovine spongiform encephalopathy. The conversion of a normal cellular form (PrP(C)) of PrP into an abnormal form (PrP(Sc)) is thought to be associated with the pathogenesis. An RNA aptamer that tightly binds to and stabilizes PrP(C) is expected to...

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Autors principals: Mashima, Tsukasa, Nishikawa, Fumiko, Kamatari, Yuji O., Fujiwara, Hiromichi, Saimura, Masayuki, Nagata, Takashi, Kodaki, Tsutomu, Nishikawa, Satoshi, Kuwata, Kazuo, Katahira, Masato
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553944/
https://ncbi.nlm.nih.gov/pubmed/23180780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1132
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