Development and structural determination of an anti-PrP(C) aptamer that blocks pathological conformational conversion of prion protein

Prion diseases comprise a fatal neuropathy caused by the conversion of prion protein from a cellular (PrP(C)) to a pathological (PrP(Sc)) isoform. Previously, we obtained an RNA aptamer, r(GGAGGAGGAGGA) (R12), that folds into a unique G-quadruplex. The R12 homodimer binds to a PrP(C) molecule, inhib...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mashima, Tsukasa, Lee, Joon-Hwa, Kamatari, Yuji O., Hayashi, Tomohiko, Nagata, Takashi, Nishikawa, Fumiko, Nishikawa, Satoshi, Kinoshita, Masahiro, Kuwata, Kazuo, Katahira, Masato
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080826/
https://ncbi.nlm.nih.gov/pubmed/32188933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61966-4
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