R164H and V240H Replacements by Site-Directed Mutagenesis of TEM-149 Extended-Spectrum β-Lactamase: Kinetic Analysis of TEM-149(H240) and TEM-149(H164-H240) Laboratory Mutants

Two laboratory mutant forms, TEM-149(H240) and TEM-149(H164-H240), of the TEM-149 extended-spectrum β-lactamase enzyme were constructed by site-directed mutagenesis. TEM-149(H240) and TEM-149(H164-H240) were similar in kinetic behavior, except with respect to benzylpenicillin and ceftazidime. Molecu...

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Main Authors: Perilli, Mariagrazia, Celenza, Giuseppe, Mercuri, Paola Sandra, Galleni, Moreno, Pellegrini, Cristina, Segatore, Bernardetta, Amicosante, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553744/
https://ncbi.nlm.nih.gov/pubmed/23183431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01268-12
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