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Biochemical Characterization of Laboratory Mutants of Extended-Spectrum β-Lactamase TEM-60
Three mutants of the extended-spectrum β-lactamase TEM-60, the P51L, K104E, and S164R mutants, were constructed by site-directed mutagenesis. The kinetic parameters of the mutated enzymes and interactions of inhibitors were significantly different from those of TEM-60, revealing that the L51P mutati...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514782/ https://ncbi.nlm.nih.gov/pubmed/15328132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3579-3582.2004 |
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