Kinetic Study of the Effect of Histidines 240 and 164 on TEM-149 Enzyme Probed by β-Lactam Inhibitors

In the present study, we performed a detailed kinetic analysis of the enzymes TEM-149, TEM-149(H240), and TEM-149(H164-H240) versus a large panel of inhibitors/inactivators, including penicillins, penems, carbapenems, monobactams, cephamycin, and carbacephem. These compounds behaved as poor substrat...

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Detalhes bibliográficos
Main Authors: Perilli, Mariagrazia, Mancini, Alisia, Celenza, Giuseppe, Bottoni, Carlo, Bellio, Pierangelo, Sabatini, Alessia, Di Pietro, Letizia, Brisdelli, Fabrizia, Segatore, Bernardetta, Amicosante, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187899/
https://ncbi.nlm.nih.gov/pubmed/25092695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02950-14
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