Biochemical Characterization of TEM-92 Extended-Spectrum β-Lactamase, a Protein Differing from TEM-52 in the Signal Peptide

A bla(TEM-92) gene was cloned from a Proteus mirabilis isolate and expressed in Escherichia coli. Production of the enzyme caused reduction of susceptibility to penicillins and narrow- to expanded-spectrum cephalosporins but not to moxalactam and cephamycins. Determination of kinetic parameters with...

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Bibliographic Details
Main Authors: Perilli, Mariagrazia, Segatore, Bernardetta, De Massis, Maria Rosaria, Pagani, Laura, Luzzaro, Francesco, Rossolini, Gian Maria, Amicosante, Gianfranco
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC132775/
https://ncbi.nlm.nih.gov/pubmed/12435705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3981-3983.2002
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