Biochemical Characterization of TEM-92 Extended-Spectrum β-Lactamase, a Protein Differing from TEM-52 in the Signal Peptide

A bla(TEM-92) gene was cloned from a Proteus mirabilis isolate and expressed in Escherichia coli. Production of the enzyme caused reduction of susceptibility to penicillins and narrow- to expanded-spectrum cephalosporins but not to moxalactam and cephamycins. Determination of kinetic parameters with...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Perilli, Mariagrazia, Segatore, Bernardetta, De Massis, Maria Rosaria, Pagani, Laura, Luzzaro, Francesco, Rossolini, Gian Maria, Amicosante, Gianfranco
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC132775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12435705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.12.3981-3983.2002
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