Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo-β-Lactamases

Metallo-β-lactamases (MBLs) have rapidly disseminated worldwide among clinically important Gram-negative bacteria and have challenged the therapeutic use of β-lactam antibiotics, particularly carbapenems. The bla(GIM-1) gene, encoding one such enzyme, was first discovered in a Pseudomonas aeruginosa...

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Hlavní autoři: Borra, Pardha Saradhi, Samuelsen, Ørjan, Spencer, James, Walsh, Timothy R., Lorentzen, Marit Sjo, Leiros, Hanna-Kirsti S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553699/
https://ncbi.nlm.nih.gov/pubmed/23208706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02227-12
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