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Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding
The budding yeast Sir2 (silent information regulator 2) protein is the founding member of the sirtuin family of NAD-dependent histone/protein deacetylases. Its function in transcriptional silencing requires both the highly conserved catalytic domain and a poorly understood N-terminal regulatory doma...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3553284/ https://ncbi.nlm.nih.gov/pubmed/23307867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.208140.112 |
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