Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding

The budding yeast Sir2 (silent information regulator 2) protein is the founding member of the sirtuin family of NAD-dependent histone/protein deacetylases. Its function in transcriptional silencing requires both the highly conserved catalytic domain and a poorly understood N-terminal regulatory doma...

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Detalhes bibliográficos
Main Authors: Hsu, Hao-Chi, Wang, Chia-Lin, Wang, Mingzhu, Yang, Na, Chen, Zhi, Sternglanz, Rolf, Xu, Rui-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553284/
https://ncbi.nlm.nih.gov/pubmed/23307867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.208140.112
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