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A Yeast Sir2 Mutant Temperature Sensitive for Silencing
A screen for Saccharomyces cerevisiae temperature-sensitive silencing mutants identified a strain with a point mutation in the SIR2 gene. The mutation changed Ser276 to Cys. This amino acid is in the highly conserved NAD(+) binding pocket of the Sir2 family of proteins. Haploid strains of either mat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2600934/ https://ncbi.nlm.nih.gov/pubmed/18845844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.094516 |
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