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Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Sirtuins with an extended N-terminal domain (NTD), represented by yeast Sir2 and human SIRT1, harbor intrinsic mechanisms for regulation of their NAD-dependent deacetylase activities. Elucidation of the regulatory mechanisms is crucial for understanding the biological functions of sirtuins and devel...
Gorde:
| Argitaratua izan da: | Genes Dev |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cold Spring Harbor Laboratory Press
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495401/ https://ncbi.nlm.nih.gov/pubmed/26109052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.265462.115 |
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