Overexpression of ATP-Binding Cassette Transporter ABCG2 as a Potential Mechanism of Acquired Resistance to Vemurafenib in BRAF(V600E) Mutant Cancer Cells

Melanoma is the most serious type of skin cancer with a high potential for metastasis and very low survival rates. The discovery of constitutive activation of the BRAF kinase caused by activating BRAF(V600E) kinase mutation in most melanoma patients led to the discovery of the first potent BRAF(V600...

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Main Authors: Wu, Chung-Pu, Sim, Hong-May, Huang, Yang-Hui, Liu, Yen-Chen, Hsiao, Sung-Han, Cheng, Hsing-Wen, Li, Yan-Qing, Ambudkar, Suresh V., Hsu, Sheng-Chieh
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553236/
https://ncbi.nlm.nih.gov/pubmed/23153455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.11.003
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