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Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy
The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteas...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552926/ https://ncbi.nlm.nih.gov/pubmed/23151455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22778 |
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