Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy

The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rodriguez, Olga Catalina, Choudhury, Sujatra, Kolukula, Vamsi, Vietsch, Eveline E., Catania, Jason, Preet, Anju, Reynoso, Katherine, Bargonetti, Jill, Wellstein, Anton, Albanese, Chris, Avantaggiati, Maria Laura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2012
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552926/
https://ncbi.nlm.nih.gov/pubmed/23151455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22778
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