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Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?
One fundamental feature of mutant forms of p53 consists in their accumulation at high levels in tumors. At least in the case of neomorphic p53 mutations, which acquire oncogenic activity, stabilization is a driving force for tumor progression. It is well documented that p53 mutants are resistant to...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Landes Bioscience
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646859/ https://ncbi.nlm.nih.gov/pubmed/23466706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24128 |
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