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Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

One fundamental feature of mutant forms of p53 consists in their accumulation at high levels in tumors. At least in the case of neomorphic p53 mutations, which acquire oncogenic activity, stabilization is a driving force for tumor progression. It is well documented that p53 mutants are resistant to...

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Detalhes bibliográficos
Main Authors: Choudhury, Sujata, Kolukula, Vamsi K., Preet, Anju, Albanese, Chris, Avantaggiati, Maria Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646859/
https://ncbi.nlm.nih.gov/pubmed/23466706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24128
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