Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy

The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteas...

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Bibliografiska uppgifter
Huvudupphovsmän: Rodriguez, Olga Catalina, Choudhury, Sujatra, Kolukula, Vamsi, Vietsch, Eveline E., Catania, Jason, Preet, Anju, Reynoso, Katherine, Bargonetti, Jill, Wellstein, Anton, Albanese, Chris, Avantaggiati, Maria Laura
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2012
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552926/
https://ncbi.nlm.nih.gov/pubmed/23151455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22778
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