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Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy

The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rodriguez, Olga Catalina, Choudhury, Sujatra, Kolukula, Vamsi, Vietsch, Eveline E., Catania, Jason, Preet, Anju, Reynoso, Katherine, Bargonetti, Jill, Wellstein, Anton, Albanese, Chris, Avantaggiati, Maria Laura
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552926/
https://ncbi.nlm.nih.gov/pubmed/23151455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22778
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