Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy

The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteas...

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Hlavní autoři: Rodriguez, Olga Catalina, Choudhury, Sujatra, Kolukula, Vamsi, Vietsch, Eveline E., Catania, Jason, Preet, Anju, Reynoso, Katherine, Bargonetti, Jill, Wellstein, Anton, Albanese, Chris, Avantaggiati, Maria Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552926/
https://ncbi.nlm.nih.gov/pubmed/23151455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22778
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