Conventional liquid chromatography/triple quadrupole mass spectrometer-based metabolite identification and semi-quantitative estimation approach in the investigation of dabigatran etexilate in vitro metabolism

Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted by esterases to dabigatran (DAB), a direct inhibitor of thrombin. To elucidate the esterase-mediated metabolic pathway of DABE, a high-performance liquid chromatography/mass spectrometer (LC-MS/MS)-based metabolite identificati...

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Hauptverfasser: Hu, Zhe-Yi, Parker, Robert B., Herring, Vanessa L., Laizure, S. Casey
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552076/
https://ncbi.nlm.nih.gov/pubmed/23239178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-012-6576-4
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