Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Sun, Zhi, Yang, Jie, Liu, Liwei, Xu, Yanyan, Zhou, Lin, Jia, Qingquan, Shi, Yingying, Du, Xiangyu, Kang, Jian, Zuo, Lihua
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843799/
https://ncbi.nlm.nih.gov/pubmed/31749700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01266
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