Determination and pharmacokinetic study of AZD‐3759 in rat plasma by ultra performance liquid chromatography with triple quadrupole mass spectrometer

BACKGROUND: AZD‐3759 is a new, potent, oral, active central nervous system‐penetrant EGFR inhibitor. Despite promising clinical activity among patients pretreated and never treated with EGFR‐tyrosine kinase inhibitors, no time saving pharmacokinetic study method has been reported in an animal model....

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發表在:Thorac Cancer
Main Authors: Wu, Qingjun, Hua, Ailian, Sun, Yaoguang, Ma, Chao, Tian, Wenxin, Huang, Chuan, Yu, Hanbo, Jiao, Peng, Wang, Shuanghu, Tong, Hongfeng, Qiu, Weiwen
格式: Artigo
語言:Inglês
出版: John Wiley & Sons Australia, Ltd 2018
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209780/
https://ncbi.nlm.nih.gov/pubmed/30252204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1759-7714.12843
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