Determination and pharmacokinetic study of AZD‐3759 in rat plasma by ultra performance liquid chromatography with triple quadrupole mass spectrometer

BACKGROUND: AZD‐3759 is a new, potent, oral, active central nervous system‐penetrant EGFR inhibitor. Despite promising clinical activity among patients pretreated and never treated with EGFR‐tyrosine kinase inhibitors, no time saving pharmacokinetic study method has been reported in an animal model....

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Foilsithe in:Thorac Cancer
Main Authors: Wu, Qingjun, Hua, Ailian, Sun, Yaoguang, Ma, Chao, Tian, Wenxin, Huang, Chuan, Yu, Hanbo, Jiao, Peng, Wang, Shuanghu, Tong, Hongfeng, Qiu, Weiwen
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons Australia, Ltd 2018
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209780/
https://ncbi.nlm.nih.gov/pubmed/30252204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1759-7714.12843
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