Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed...

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Vydáno v:Front Pharmacol
Hlavní autoři: Sun, Zhi, Yang, Jie, Liu, Liwei, Xu, Yanyan, Zhou, Lin, Jia, Qingquan, Shi, Yingying, Du, Xiangyu, Kang, Jian, Zuo, Lihua
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843799/
https://ncbi.nlm.nih.gov/pubmed/31749700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01266
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