Sildenafil restores endothelial function in the apolipoprotein E knockout mouse

BACKGROUND: Atherosclerosis is an inflammatory process of the arterial walls and is initiated by endothelial dysfunction accompanied by an imbalance in the production of reactive oxygen species (ROS) and nitric oxide (NO). Sildenafil, a selective phosphodiesterase-5 (PDE5) inhibitor used for erectil...

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Autori principali: Balarini, Camille M, Leal, Marcos A, Gomes, Isabele B S, Pereira, Thiago M C, Gava, Agata L, Meyrelles, Silvana S, Vasquez, Elisardo C
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551739/
https://ncbi.nlm.nih.gov/pubmed/23289368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-3
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