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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions

FTDP-17 mutations in the tau gene lead to early-onset frontotemporal dementias characterized by the pathological aggregation of the microtubule-associated protein tau. Tau aggregation is closely correlated with the progression and severity of localized atrophy of certain regions in the brain. These...

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Bibliografiske detaljer
Main Authors: Combs, Benjamin, Gamblin, T. Chris
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548947/
https://ncbi.nlm.nih.gov/pubmed/23043292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3010818
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