A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo

The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau. In vitro, FTDP-17 mutant versions of tau can reduce microtubule binding and i...

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Foilsithe in:J Neurosci
Main Authors: Bardai, Farah H., Wang, Liqun, Mutreja, Yamini, Yenjerla, Mythili, Gamblin, T. Chris, Feany, Mel B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2018
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Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
https://ncbi.nlm.nih.gov/pubmed/29138281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1550-17.2017
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