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Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the molecular connection between tau and Parkinso...
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| Publicado no: | PLoS Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6319772/ https://ncbi.nlm.nih.gov/pubmed/30571694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006265 |
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