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α-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton
Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the pathogenesis of Parkinson’s disease and related α-synucleinopathies. Here we describe a new Drosophila model of α-synucleinopathy based on widespread expression of wild type human α-synuclein, which shows robu...
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| Published in: | Neuron |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5755717/ https://ncbi.nlm.nih.gov/pubmed/29249285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.11.036 |
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