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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions
FTDP-17 mutations in the tau gene lead to early-onset frontotemporal dementias characterized by the pathological aggregation of the microtubule-associated protein tau. Tau aggregation is closely correlated with the progression and severity of localized atrophy of certain regions in the brain. These...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548947/ https://ncbi.nlm.nih.gov/pubmed/23043292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3010818 |
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