FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics: AN “ALTERNATIVE CORE” MODEL FOR NORMAL AND PATHOLOGICAL TAU ACTION

Mutations affecting either the structure or regulation of the microtubule-associated protein Tau cause neuronal cell death and dementia. However, the molecular mechanisms mediating these deleterious effects remain unclear. Among the most characterized activities of Tau is the ability to regulate mic...

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Détails bibliographiques
Auteurs principaux: LeBoeuf, Adria C., Levy, Sasha F., Gaylord, Michelle, Bhattacharya, Arnab, Singh, Ambuj K., Jordan, Mary Ann, Wilson, Leslie, Feinstein, Stuart C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606000/
https://ncbi.nlm.nih.gov/pubmed/18940799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803519200
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