Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

In the present study, Hu-Mikβ1, a humanized mAb directed at the shared IL-2/IL-15Rβ subunit (CD122) was evaluated in patients with T-cell large granular lymphocytic (T-LGL) leukemia. Hu-Mikβ1 blocked the trans presentation of IL-15 to T cells expressing IL-2/IL-15Rβ and the common γ-chain (CD132), b...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Waldmann, Thomas A., Conlon, Kevin C., Stewart, Donn M., Worthy, TatYana A., Janik, John E., Fleisher, Thomas A., Albert, Paul S., Figg, William D., Spencer, Shawn D., Raffeld, Mark, Decker, Jean R., Goldman, Carolyn K., Bryant, Bonita R., Petrus, Michael N., Creekmore, Stephen P., Morris, John C.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2013
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548167/
https://ncbi.nlm.nih.gov/pubmed/23212516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450585
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires