Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia were treated in a phase I dose-escalation trial with the murine monoclonal antibody Mikβ1. Mikβ1 identifies CD122, the β-subunit shared by the IL-2 and IL-15 receptors. At the doses administered in this stu...

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Main Authors: Morris, John C., Janik, John E., White, Jeffrey D., Fleisher, Thomas A., Brown, Margaret, Tsudo, Mitsuru, Goldman, Carolyn K., Bryant, Bonita, Petrus, Michael, Top, Lois, Lee, Cathryn C., Gao, Wendy, Waldmann, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326174/
https://ncbi.nlm.nih.gov/pubmed/16387851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509575103
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