Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia were treated in a phase I dose-escalation trial with the murine monoclonal antibody Mikβ1. Mikβ1 identifies CD122, the β-subunit shared by the IL-2 and IL-15 receptors. At the doses administered in this stu...

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Hauptverfasser: Morris, John C., Janik, John E., White, Jeffrey D., Fleisher, Thomas A., Brown, Margaret, Tsudo, Mitsuru, Goldman, Carolyn K., Bryant, Bonita, Petrus, Michael, Top, Lois, Lee, Cathryn C., Gao, Wendy, Waldmann, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326174/
https://ncbi.nlm.nih.gov/pubmed/16387851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509575103
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